Author

Sabrina Johanna Fletcher

Candiolo Cancer InstituteORCID 0000-0002-1371-9669Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Alberto PuliafitoiD· 2 shared Andrea BertottiiD· 2 shared Elena GrassiiD· 2 shared Federica GalvagnoiD· 2 shared Letizia Pizzini· 2 shared Luca PrimoiD· 2 shared Advait SubramanianiD· 1 shared Alan D. FrankeliD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

Alberto PuliafitoORCID

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3 papers

Recent·Most cited

Inference of lineage hierarchies, growth and drug response mechanisms in cancer cell populations without tracking

Andrea Piras, Federica Galvagno, Letizia Pizzini, Matteo Nunziante, Sabrina Johanna Fletcher, Elena Grassi, Andrea Bertotti, Luca Primo, Antonio Celani, Alberto Puliafito

This study introduces a method to infer lineage hierarchies and drug response mechanisms in cancer cell populations without single-cell tracking, demonstrating its effectiveness through simulations and experiments.

Cell Reports Methods · Aug 17, 2026Peer-reviewedCancer Biology

TGF-β1-induced differentiation enhances chemotherapy response in metastatic colorectal cancer organoids

Sabrina Johanna Fletcher, Letizia Pizzini, Irene Catalano, Miriam Palmiero, Federica Galvagno, Sofia Borgato, Elena Grassi, Andrea Bertotti, Luca Primo, Livio Trusolino, Alberto Puliafito

This study shows that TGF-β1-induced differentiation in colorectal cancer organoids enhances chemotherapy response by reducing clonogenic capacity and increasing oxaliplatin cytotoxicity.

bioRxiv · Jun 8, 2026 · PreprintCancer Biology

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia Richards, Beril Tutuncuoglu, , Natalia Jura

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

Nature · Apr 30, 2020Peer-reviewedSystems Biology✦ In-depth digest