Alberto Puliafito

This study introduces a method to infer lineage hierarchies and drug response mechanisms in cancer cell populations without single-cell tracking, demonstrating its effectiveness through simulations and experiments.

This study shows that TGF-β1-induced differentiation in colorectal cancer organoids enhances chemotherapy response by reducing clonogenic capacity and increasing oxaliplatin cytotoxicity.

This study identifies Cul-5 as a regulator of nuclear positioning in Drosophila embryos and shows how the nuclear-to-cytoplasmic ratio is sensed to control the mid-blastula transition.