Author

Hannah Felstead

University of CambridgeORCID 0000-0002-1295-2186Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Andrew Lim· 1 shared Arthur Alves de MeloiD· 1 shared Bryan D. RyderiD· 1 shared Daniel R. SouthworthiD· 1 shared Danna Trejos-VidaliD· 1 shared Eric TseiD· 1 shared Jason E. GestwickiiD· 1 shared John SkidmoreiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Andrew Lim

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1 paper

Recent·Most cited

Resolving the Activation Mechanism of the Human 20S Proteasome

Bryan D. Ryder, N. Yan, Danna Trejos-Vidal, Patricia Martínez-Botía, Julian R. Braxton, Andrew Lim, Hannah Felstead, Steve Andrews, Eric Tse, Arthur Alves de Melo, John Skidmore, Miguel A. Prado, Daniel R. Southworth, Jason E. Gestwicki

This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.

bioRxiv · Apr 15, 2026 · PreprintBiophysics