John Skidmore

The paper identifies three GCN2 activators, one of which works independently of GCN1, and describes its unique binding mechanism.

The paper identifies HUWE1, USP33, and USP20 as negative regulators of autophagy/mitophagy through cross-platform screening and validates their roles in neurodegeneration using multiple models.

This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.

This study identifies HOIP and linear ubiquitin chains as critical for TRIM21-mediated ADIN by recruiting VCP, enhancing virus neutralization.