Author

Patricia Martínez-Botía

Instituto de Investigación Sanitaria del Principado de AsturiasORCID 0000-0002-9778-5945Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jason E. GestwickiiD· 2 shared Miguel A. PradoiD· 2 shared Alejandro Rodríguez GamaiD· 1 shared Alfred C.O. VertegaaliD· 1 shared Andrew Lim· 1 shared Arthur Alves de MeloiD· 1 shared Bryan D. RyderiD· 1 shared Daniel J. FinleyiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioinformatics

Jason E. GestwickiORCID

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2 papers

Recent·Most cited

Survey of the human proteostasis network: the ubiquitin-proteasome system

Suzanne Elsasser, Evan T. Powers, Thomas Stoeger, Xiaojing Sui, Roy D. Kurtzbard, Patricia Martínez-Botía, Margaret A. Wangeline, Alejandro Rodríguez Gama, Edward L. Huttlin, Lisa P. Elia, Jeffery W. Kelly, Jason E. Gestwicki, Judith Frydman, Steven M. Finkbeiner, Eugenia M. Clérico, , Daniel J. Finley

The paper provides a comprehensive survey of the ubiquitin-proteasome system (UPS) and estimates its size and scope within the human proteostasis network.

Autophagy · Oct 29, 2026Peer-reviewedBioinformatics

Resolving the Activation Mechanism of the Human 20S Proteasome

Bryan D. Ryder, N. Yan, Danna Trejos-Vidal, Patricia Martínez-Botía, Julian R. Braxton, Andrew Lim, Hannah Felstead, Steve Andrews, Eric Tse, Arthur Alves de Melo, John Skidmore, Miguel A. Prado, Daniel R. Southworth, Jason E. Gestwicki

This study identifies a conserved leucine in the C-terminus of proteasome activators as essential for gate opening of the human 20S proteasome, with structural and functional evidence supporting its role.

bioRxiv · Apr 15, 2026 · PreprintBiophysics