Jacquin C. Niles

The paper identifies potent reaction hijacking inhibitors targeting Plasmodium falciparum asparagine tRNA synthetase, showing high selectivity and resistance refractoriness.

The paper develops two inducible transcriptional repression systems in Plasmodium falciparum, achieving significant repression and enabling functional genomics studies.

This study identifies divergent resistance mechanisms in Plasmodium HSP90 inhibitors despite shared binding sites, showing that enhanced binding can paradoxically correlate with resistance.

This study shows that CHIR-124, a human Chk1 inhibitor, is active against Plasmodium falciparum through dual inhibition of PfArk1 and hemozoin formation, suggesting polypharmacology as a strategy for antimalarial drugs.

The paper identifies PfArk1 as a key target for antimalarial drugs by showing that inhibiting it disrupts parasite mitosis and nuclear division.

The paper identifies antimalarial compounds that inhibit ApiAP2 proteins in Plasmodium falciparum by screening small molecules against the AP2-EXP domain and validating their effects on parasite gene regulation and growth.