Author

Dominic S. Alonzi

University of OxfordORCID 0000-0002-1330-9109Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea LiaiD· 1 shared Andrew QuigleyiD· 1 shared Angelo SantinoiD· 1 shared Bibek GooptuiD· 1 shared Carlos Pablo ModenuttiiD· 1 shared Charlie J. HitchmaniD· 1 shared Cristian V. A. MunteanuiD· 1 shared Daniele Di BellaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrea LiaORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintJan 29, 2025

C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex

Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia…·Pietro Roversi

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

DOI 10.1101/2025.01.29.635535

cryo-EMexperimental assay