Author

Angelo Santino

Institute of Sciences of Food ProductionORCID 0000-0002-3348-0747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea LiaiD· 1 shared Andrew QuigleyiD· 1 shared Bibek GooptuiD· 1 shared Carlos Pablo ModenuttiiD· 1 shared Charlie J. HitchmaniD· 1 shared Cristian V. A. MunteanuiD· 1 shared Daniele Di BellaiD· 1 shared Dominic S. AlonziiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrea LiaORCID

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1 paper

Recent·Most cited

C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex

Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia, Geander M. Pessoa, Gabriela N. Chirițoiu, Cristian V. A. Munteanu, Juan Ortigosa, Jorge Octavio Lannot, Simona Ghenea, Ikuo Wada, Maria De Benedictis, Gábor Tax, Yusupha Bayo, Irene Crescioli, Laura Sanna, , Pietro Roversi

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

bioRxiv · Jan 29, 2025 · PreprintBiochemistry