Author

Pietro Roversi

University of LeicesterORCID 0000-0001-9280-9437Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea LiaiD· 2 shared Daniele Di BellaiD· 2 shared Andrew QuigleyiD· 1 shared Angelo SantinoiD· 1 shared Bibek GooptuiD· 1 shared Carlos Pablo ModenuttiiD· 1 shared Charlie J. HitchmaniD· 1 shared Cristian V. A. MunteanuiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioinformatics

Andrea LiaORCID

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3 papers

Recent·Most cited

BioinformaticsWellcome Open ResearchPeer-reviewedMar 19, 2026

Mathematical modelling of mutant glycoprotein fate in the ER

Daniele Di Bella, Andrea Lia, Pietro Roversi

The paper models the fate of mutant glycoproteins in the ER using an ODE framework to compare the effects of UGGT and ER mannosidase inhibition on ERQC and ERAD dynamics.

1 citation

statistical modelsimulation

𝕏 PostBluesky

BiochemistryArchives of Biochemistry and BiophysicsPeer-reviewedFeb 28, 2026

Structural, dynamic, and evolutionary determinants of substrate binding in the tetrameric 6-phosphogluconate dehydrogenase from Gluconobacter oxydans

Pablo Maturana, Pablo Villalobos, Pietro Roversi, Ricardo Cabrera

This study identifies a substrate-induced quaternary-tightening mechanism in tetrameric 6PGDH from Gluconobacter oxydans, revealing how conserved C-terminal elements regulate substrate binding and catalysis.

DOI 10.1016/j.abb.2026.110779

bacteria (other)protein structure

𝕏 PostBluesky

BiochemistrybioRxivPreprintJan 29, 2025

C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex

Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia…·Pietro Roversi

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

DOI 10.1101/2025.01.29.635535

cryo-EMexperimental assay

𝕏 PostBluesky