Author

Andrea Lia

University of SalentoORCID 0000-0003-4146-0647Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Daniele Di BellaiD· 2 shared Pietro RoversiiD· 2 shared Alice PievaniiD· 1 shared Andrea BiondiiD· 1 shared Andrew QuigleyiD· 1 shared Angelo SantinoiD· 1 shared Antonio GaleoneiD· 1 shared Antonio Maria AlvianoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Daniele Di BellaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintApr 24, 2026

Differential TIM-3 glycosylation enables specific dual targeting CAR-T therapy in acute myeloid leukemia

Marta Biondi, Antonio Galeone, Corinne Arsuffi…·Marta Serafini

This study develops a dual CAR-T therapy targeting CD33 and TIM-3 in AML, showing improved specificity and efficacy through glycosylation-modulated TIM-3 recognition.

DOI 10.64898/2026.04.22.719217

humanproteomics

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BioinformaticsWellcome Open ResearchPeer-reviewedMar 19, 2026

Mathematical modelling of mutant glycoprotein fate in the ER

Daniele Di Bella, Andrea Lia, Pietro Roversi

The paper models the fate of mutant glycoproteins in the ER using an ODE framework to compare the effects of UGGT and ER mannosidase inhibition on ERQC and ERAD dynamics.

1 citation

statistical modelsimulation

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BiochemistrybioRxivPreprintJan 29, 2025

C-terminal domain mobility underpins substrate engagement by the Chaetomium thermophilum EDEM:PDI ERAD-L checkpoint complex

Charlie J. Hitchman, Andrea Lia, Mohammed Bhogadia…·Pietro Roversi

The paper determines Cryo-EM structures of the EDEM:PDI complex with and without a substrate, revealing how disulfide bonds regulate conformational changes essential for substrate engagement.

DOI 10.1101/2025.01.29.635535

cryo-EMexperimental assay

𝕏 PostBluesky