Author

George T Chen

University of California, Los AngelesORCID 0000-0002-1342-0835Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Daniel H. GeschwindiD· 3 shared Alysson Renato MuotriiD· 1 shared Arthur S. LeeiD· 1 shared Aubrey J. Osorio· 1 shared Benjamin D. PhilpotiD· 1 shared Beth MartiniD· 1 shared Bogdan PaşaniuciD· 1 shared Brie WamsleyiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Daniel H. GeschwindORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintNov 4, 2025

Large-scale discovery of neural enhancers for cis-regulation therapies

Troy A. McDiarmid, Nicholas F. Page, Florence M. Chardon…·Jay Shendure

The paper identifies active human neural enhancers and CRISPRa gRNAs that upregulate NDD risk genes, providing a resource for cis-regulatory therapy development.

3 citations

humanmouse

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 13, 2024

Enhancer-targeted CRISPR-A rescues haploinsufficiency and mutant phenotypes in organoid models of autism

George T Chen, Gayatri Nair, Aubrey J. Osorio…·Daniel H. Geschwind

This study uses CRISPR-A to enhance expression of CHD8 and SCN2A in organoids, rescuing haploinsufficiency and associated phenotypes in ASD models.

9 citations

humanCRISPR screen

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NeurosciencebioRxivPreprintDec 17, 2020

Broad transcriptomic dysregulation across the cerebral cortex in ASD

Jillian R. Haney, Brie Wamsley, George T Chen…·Daniel H. Geschwind

The paper identifies widespread transcriptomic dysregulation across multiple cortical regions in ASD, showing regional variation and genetic enrichment in synaptic and protein folding genes.

21 citations

humanbulk RNA-seq

𝕏 PostBluesky