Author

Glen Lester Sequiera

University of British ColumbiaORCID 0000-0002-1351-8699Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Mahmoud A. PouladiiD· 3 shared Chris KayiD· 2 shared Hailey Findlay BlackiD· 2 shared Huu Phuc NguyeniD· 2 shared Larissa ArningiD· 2 shared Maurice A. CurtisiD· 2 shared Michael R. HaydeniD· 2 shared Richard L. M. FaulliD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersGenetics

Mahmoud A. PouladiORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 8, 2026

Synonymous HTT CAA/CCA-loss variants associated with early Huntington disease onset enhance toxicity beyond somatic instability

Glen Lester Sequiera, Sophia C. Gjervan, Ryan T. McCallum…·Mahmoud A. Pouladi

This study shows that HTT CAA/CCA-loss variants increase toxicity in Huntington disease models independently of somatic repeat instability.

DOI 10.64898/2026.09.03.749261

humanproteomics

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NeurosciencebioRxivPreprintMar 5, 2026

Loss of interruption in the HTT CAG repeat is associated with increased somatic expansion and loss of medium spiny neurons in HD

Chris Kay, Jessica Q. Dawson, Kert Mätlik…·Michael R. Hayden

The paper shows that loss of interruption in HTT CAG repeats increases somatic expansion and MSN loss in HD, with greater effects in patients with CAG-CCG LOI.

1 citation

humanstatistical model

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Cell BiologybioRxivFeb 7, 2024

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

Manisha Yadav, Rachel J. Harding, Tiantian Li…·Cheryl H. Arrowsmith

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

DOI 10.1126/sciadv.ado5264

humanbulk RNA-seq

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