Author

Larissa Arning

Ruhr University BochumORCID 0000-0002-8913-5627Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Huu Phuc NguyeniD· 4 shared Caroline SchlüteriD· 2 shared Chris KayiD· 2 shared Christoph FraenziD· 2 shared Dorothea MetzeniD· 2 shared Erhan GençiD· 2 shared Fabian StreitiD· 2 shared Glen Lester SequieraiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersGenetics

Huu Phuc NguyenORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 8, 2026

Synonymous HTT CAA/CCA-loss variants associated with early Huntington disease onset enhance toxicity beyond somatic instability

Glen Lester Sequiera, Sophia C. Gjervan, Ryan T. McCallum…·Mahmoud A. Pouladi

This study shows that HTT CAA/CCA-loss variants increase toxicity in Huntington disease models independently of somatic repeat instability.

DOI 10.64898/2026.09.03.749261

humanproteomics

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NeurosciencebioRxivPreprintMar 5, 2026

Loss of interruption in the HTT CAG repeat is associated with increased somatic expansion and loss of medium spiny neurons in HD

Chris Kay, Jessica Q. Dawson, Kert Mätlik…·Michael R. Hayden

The paper shows that loss of interruption in HTT CAG repeats increases somatic expansion and MSN loss in HD, with greater effects in patients with CAG-CCG LOI.

1 citation

humanstatistical model

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GeneticsHuman Brain MappingPeer-reviewedApr 4, 2023

Structural architecture and brain network efficiency links polygenic scores to intelligence

Erhan Genç, Dorothea Metzen, Christoph Fraenz…·Robert Kumsta

This study links polygenic scores for intelligence and educational attainment to brain structure and network efficiency, showing mediation through fiber connectivity and parieto-frontal surface area.

13 citations

humanbulk RNA-seq

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GeneticsMolecular NeurobiologyPeer-reviewedMay 5, 2021

Polygenic Scores for Cognitive Abilities and their Association with Different Aspects of General Intelligence - a Deep Phenotyping Approach

Erhan Genç, Caroline Schlüter, Christoph Fraenz…·Sebastian Ocklenburg

This study evaluates polygenic scores for intelligence and cognitive performance in a sample of 557 adults, finding they predict different facets of intelligence with varying accuracy.

67 citationstop 1%

humanGWAS summary statistics

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