Author

Chris Kay

University of British ColumbiaORCID 0000-0002-8170-4805Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Glen Lester SequieraiD· 2 shared Hailey Findlay BlackiD· 2 shared Huu Phuc NguyeniD· 2 shared Larissa ArningiD· 2 shared Mahmoud A. PouladiiD· 2 shared Michael R. HaydeniD· 2 shared Tanushri Soomarooah· 2 shared A. Nazlı BaşakiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenetics

Glen Lester SequieraORCID

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2 papers

Recent·Most cited

Synonymous HTT CAA/CCA-loss variants associated with early Huntington disease onset enhance toxicity beyond somatic instability

Glen Lester Sequiera, Sophia C. Gjervan, Ryan T. McCallum, Jia Feng, Oguz K. Ozgoren, Sofia Bergh, Jocelyn Bégin, Jessica Dawson, Hailey Findlay Black, Chris Kay, Tanushri Soomarooah, Larissa Arning, Indhu‐Shree Rajan‐Babu, A. Nazlı Başak, Jiří Klempíř, , Mahmoud A. Pouladi

This study shows that HTT CAA/CCA-loss variants increase toxicity in Huntington disease models independently of somatic repeat instability.

bioRxiv · Sep 8, 2026 · PreprintGenetics

Loss of interruption in the HTT CAG repeat is associated with increased somatic expansion and loss of medium spiny neurons in HD

Chris Kay, Jessica Q. Dawson, Kert Mätlik, Hailey Findlay Black, Emily M. Harvey, Stephanie Bortnick, Kyla Javier, Christina Maree Buchanan, Tanushri Soomarooah, Inês Caldeira Brás, Glen Lester Sequiera, Mahmoud A. Pouladi, Larissa Arning, Huu Phuc Nguyen, Richard H Roxburgh, , Michael R. Hayden

The paper shows that loss of interruption in HTT CAG repeats increases somatic expansion and MSN loss in HD, with greater effects in patients with CAG-CCG LOI.

bioRxiv · Mar 5, 2026 · PreprintNeuroscience