Author

Ryan T. McCallum

University of British ColumbiaORCID 0000-0002-0876-0595Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

A. Nazlı BaşakiD· 1 shared Åsa PeterséniD· 1 shared Cecilia B. Micelli· 1 shared Chris KayiD· 1 shared Glen Lester SequieraiD· 1 shared Hailey Findlay BlackiD· 1 shared Huu Phuc NguyeniD· 1 shared Indhu‐Shree Rajan‐BabuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

A. Nazlı BaşakORCID

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2 papers

Recent·Most cited

Synonymous HTT CAA/CCA-loss variants associated with early Huntington disease onset enhance toxicity beyond somatic instability

Glen Lester Sequiera, Sophia C. Gjervan, Ryan T. McCallum, Jia Feng, Oguz K. Ozgoren, Sofia Bergh, Jocelyn Bégin, Jessica Dawson, Hailey Findlay Black, Chris Kay, Tanushri Soomarooah, Larissa Arning, Indhu‐Shree Rajan‐Babu, A. Nazlı Başak, Jiří Klempíř, , Mahmoud A. Pouladi

This study shows that HTT CAA/CCA-loss variants increase toxicity in Huntington disease models independently of somatic repeat instability.

bioRxiv · Sep 8, 2026 · PreprintGenetics

Prenatal exposure to valproic acid induces sex-specific alterations in cortical and hippocampal neuronal structure and function in rats

Olivia O. F. Williams, Madeleine Coppolino, Cecilia B. Micelli, Ryan T. McCallum, Paula T Henry-Duru, Joshua D. Manduca, Jasmin Lalonde, Melissa L. Perreault

This study examines sex-specific effects of prenatal valproic acid exposure on neuronal structure and function in rat cortical and hippocampal neurons, revealing differences in activity, morphology, and gene expression.

bioRxiv · Sep 3, 2024 · PreprintNeuroscience