Author

Daniel Thédié

University of EdinburghORCID 0000-0002-1352-7245Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Alessia LeporeiD· 2 shared Lorna McLareniD· 2 shared Meriem El KarouiiD· 2 shared Achillefs N. KapanidisiD· 1 shared Benura AzerogluiD· 1 shared Oliver J. PambosiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

Alessia LeporeORCID

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2 papers

Recent·Most cited

Spatio-temporal coordination of the DNA Double-Strand Break repair machinery in Escherichia coli

Daniel Thédié, Alessia Lepore, Lorna McLaren, Meriem El Karoui

This study quantifies RecB dynamics at DNA double-strand breaks in E. coli, showing long-lived complexes and intrinsic dissociation properties, and uses RecB binding to estimate damage formation rates.

bioRxiv · Dec 18, 2024 · PreprintMicrobiology

In vivo single-molecule imaging of RecB reveals efficient repair of DNA damage in Escherichia coli

Alessia Lepore, Daniel Thédié, Lorna McLaren, Benura Azeroglu, Oliver J. Pambos, Achillefs N. Kapanidis, Meriem El Karoui

This study uses single-molecule imaging in E. coli to show that RecB facilitates efficient DNA repair without activating the SOS response, while a modified RecB leads to less efficient repair and high SOS induction.

bioRxiv · Dec 22, 2023 · PreprintMolecular Biology