Author

Javier Emperador-Melero

Harvard UniversityORCID 0000-0002-1364-4935Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Pascal S. KaeseriD· 4 shared Giovanni de NolaiD· 3 shared Aaron D. LevyiD· 1 shared Avital Adah RodaliD· 1 shared Hajnalka NyitraiiD· 1 shared Jonathan W. Andersen· 1 shared Kevin M De León González· 1 shared Man Yan Wong· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Pascal S. KaeserORCID

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4 papers

Recent·Most cited

Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release

Javier Emperador-Melero, Steven J. Del Signore, Kevin M De León González, Pascal S. Kaeser, Avital Adah Rodal

This study shows that endocytic protein localization to periactive zones in synapses is independent of active zone assembly and synaptic activity.

eLife · Jun 17, 2026Peer-reviewedNeuroscience

Molecular definition of distinct active zone protein machineries for Ca2+ channel clustering and synaptic vesicle priming

Javier Emperador-Melero, Jonathan W. Andersen, Sarah R. Metzbower, Aaron D. Levy, Poorna A. Dharmasri, Giovanni de Nola, Thomas A. Blanpied, Pascal S. Kaeser

The paper identifies distinct molecular machineries for Ca2+ channel clustering and synaptic vesicle priming at active zones, showing that Liprin- and PTPσ specifically support priming site assembly.

bioRxiv · Oct 27, 2023 · PreprintNeuroscience

Phosphorylation triggers presynaptic phase separation of Liprin-α3 to control active zone structure

Javier Emperador-Melero, Man Yan Wong, Shan Shan H. Wang, Giovanni de Nola, Hajnalka Nyitrai, Tomas L. Kirchhausen, Pascal S. Kaeser

This study shows phosphorylation of Liprin-3 triggers phase separation to regulate presynaptic active zone structure and function.

Nature Communications · May 24, 2021Peer-reviewedNeuroscience

Intact synapse structure and function after combined knockout of PTPδ, PTPσ and LAR

Javier Emperador-Melero, Giovanni de Nola, Pascal S. Kaeser

This study investigates the role of LAR-RPTPs in synapse structure and function by analyzing triple knockout mice, finding they are dispensable for presynaptic organization and function.

eLife · Mar 3, 2021Peer-reviewedNeuroscience