Poorna A. Dharmasri

Trans-synaptic molecular context of NMDA receptor nanodomains

The paper maps the spatial relationships between NMDA receptor subunits and synaptic proteins, revealing a nanotopography that promotes NMDAR activation and synaptic transmission tuning.

Distinct SAP102 and PSD-95 nano-organization defines multiple types of synaptic scaffold protein domains at single synapses

This study uses super-resolution microscopy to show that SAP102 forms distinct nanoclusters at synapses, differing from PSD-95 in size, density, and co-localization patterns.

Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons

The paper compares nanoscale organization of excitatory synapses onto excitatory and inhibitory neurons, finding conserved and cell-specific structural differences.

Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95

This study shows that loss of NMDARs leads to changes in pre- and postsynaptic nanocluster organization, affecting synaptic function differently than pharmacological antagonism.

Molecular definition of distinct active zone protein machineries for Ca2+ channel clustering and synaptic vesicle priming

The paper identifies distinct molecular machineries for Ca2+ channel clustering and synaptic vesicle priming at active zones, showing that Liprin- and PTPσ specifically support priming site assembly.