Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors
Ricardo C. López, Natalie Noble, Özge Demet Özçete, Xintong Cai, Gillian E. Handy, Jonathan W. Andersen, Tommaso Patriarchi, Yulong Li, Pascal S. Kaeser
The paper shows that high innervation density of cross-reacting transmitters causes non-specific activation of GPCR-based sensors, requiring specific innervation silencing for accurate interpretation.
bioRxiv · Nov 23, 2024 · PreprintNeuroscience