HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis
Izadora de Souza, Izabela Amélia Marques de Andrade, Florêncio Porto Freitas, Ana Beatriz da Silva Teixeira, Maria Carolina Clares Ramalho, Karoline Almeida, Ancély Ferreira dos Santos, Werner Schmitz, Gholamreza Fazeli, Clarissa Ribeiro Reily Rocha, José Pedro Friedmann Angeli
This study identifies a heme-HMOX1-ferritin axis that protects cells from ferroptosis by stabilizing heme and upregulating ferritin when HMOX1 is inactive.
Science Advances · Aug 19, 2026Peer-reviewedCancer Biology