Rachael Wasikowski

Disease context dictates the cellular targets of IL-17 in inflammatory skin disease

This study shows that IL-17 targets different cell types in inflammatory skin diseases, with fibroblasts being key in hidradenitis suppurativa and both fibroblasts and keratinocytes in psoriasis.

Disease-specific differences in particulate matter handling drive pathogenic responses in human derived nasal epithelial cells

The paper investigates how particulate matter exposure affects nasal epithelial cells in chronic rhinosinusitis (CRS) and controls, finding amplified inflammatory and barrier dysfunction responses in CRS cells.

singIST: an integrative method for comparative single-cell trancriptomics between disease models and humans

singIST quantifies disease model similarity to human conditions at single-cell resolution using pathway and cell type-level measures, demonstrating its utility in atopic dermatitis models.

Restoration of Keratinocyte Homeostasis Drives Resolution of Skin Inflammation

The paper shows that restoring keratinocyte homeostasis reduces skin inflammation by reversing gene programs and normalizing epidermal architecture in a murine model.

Cross-disease comparison of dermatomyositis and lupus skin identifies inflammatory monocytes and JAK-1 signaling as drivers of vasculopathy in dermatomyositis

This study compares dermatomyositis and lupus skin lesions using single-cell RNA-sequencing to identify inflammatory monocytes and JAK-1 signaling as drivers of vasculopathy in dermatomyositis.

TWEAK Signaling Drives the Transition from Psoriasis to Atopic Dermatitis-like Inflammation in Paradoxical Skin Reactions

The paper identifies TWEAK-IL-13 signaling as a driver of paradoxical skin reactions following anti-TNF, IL-17, or IL-23 therapy.

Positionally distinct interferon stimulated dermal immune acting fibroblasts promote neutrophil recruitment in Sweet's syndrome

This study identifies interferon-responsive dermal fibroblasts in Sweet's syndrome that promote neutrophil recruitment through chemokine expression and spatial positioning.

VGLL3-centered network connects placental, vascular, and immune defects in preeclampsia

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.

This study creates a high-resolution single-cell atlas of healthy human skin, revealing region-specific transcriptional networks and their links to inflammatory diseases.

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

Multi-Ancestry Genome-Wide Association Meta-Analysis Identifies Novel Loci in Atopic Dermatitis

This study conducts a multi-ancestry GWAS meta-analysis of 56,146 AD cases and 602,280 controls, identifying 101 genomic loci, 15 novel to AD or eczema, and linking them to AD pathophysiology through functional analyses.

Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.

Double triage to identify poorly annotated genes in Maize: The missing link in community curation

The paper identifies poorly annotated genes in maize using a double triage approach combining quality metrics and gene tree visualization, revealing 4,000 novel annotations.