TWIST1 mediated transcriptional activation of SPON2 drives colorectal peritoneal metastasis through activation of cancer-associated fibroblast signaling network
Zhuan Zhou, Alessandro La Ferlita, Manoj H. Palavalli, Xiongfeng Chen, Lauren A. Tyler, Aslam M. Ejaz, Joal D. Beane, Patricio Marcelo Polanco, Huocong Huang, Alex C. Kim
This study identifies the SPP1-TWIST1-SPON2 signaling axis as a driver of colorectal peritoneal metastasis through cancer-associated fibroblast signaling.
bioRxiv · Apr 11, 2025 · PreprintCancer Biology