Huocong Huang

Dissecting the Dynamic Evolution of Tensional Homeostasis in Fibroblasts using an Integrated Biomechanical Bioreactor Platform

This study uses a biomechanical bioreactor to show that fibroblasts adjust stress dynamically with collagen concentration, revealing a balance between contractility and matrix densification.

Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA-driven tumorigenesis

This study shows that the cGAS-STING pathway suppresses ecDNA-driven tumorigenesis by detecting ecDNA fragments and restricting their formation.

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment

This study shows ecDNA-driven oncogene super-expressors create an immunoevasive tumor microenvironment in PDAC by promoting myCAF expansion and suppressing T cell infiltration.

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Pan-cancer single-cell and spatial profiling resolves two antigen-presenting CAF lineages: tumor-adjacent mesothelial-like apCAFs and tertiary lymphoid structure-associated fibrocyte-like apCAFs, both secreting pro-tumorigenic SPP1.

A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populations

This study identifies cellular and microenvironmental factors contributing to radiation therapy resistance in pancreatic cancer using spatial transcriptomics and single-cell RNA sequencing.

TWIST1 mediated transcriptional activation of SPON2 drives colorectal peritoneal metastasis through activation of cancer-associated fibroblast signaling network

This study identifies the SPP1-TWIST1-SPON2 signaling axis as a driver of colorectal peritoneal metastasis through cancer-associated fibroblast signaling.