Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches
Xiongfeng Chen, Zhuan Zhou, Luyu Xie, Kailiang Qiao, Yiyue Jia, Si Liu, Zeynep Yazgan, Francesca Rossi, Yang Liu, Bo Zhang, Patricio Marcelo Polanco, Herbert J. Zeh, Alex C. Kim, Huocong Huang
Pan-cancer single-cell and spatial profiling resolves two antigen-presenting CAF lineages: tumor-adjacent mesothelial-like apCAFs and tertiary lymphoid structure-associated fibrocyte-like apCAFs, both secreting pro-tumorigenic SPP1.
Cancer Cell · Sep 25, 2025Peer-reviewedCancer Biology✦ In-depth digest