Alexander Mendenhall

ACE identifies universal aging signatures across species by disentangling aging-related gene expression from other biological variations using explainable AI.

The paper quantifies interindividual variation in allele-specific expression across healthy human tissues using GTEx data, revealing gene-specific patterns and tissue-specific biases.

The paper identifies maternal histone methyltransferases that antagonistically regulate monoallelic expression in C. elegans intestinal progenitor cells.

The paper shows introns reduce stochasticity in metazoan gene expression by controlling allele bias through a 5-position dependent mechanism.

The paper identifies hsp-16.2 chaperone biomarkers as indicators of proteome dosage states in C. elegans, revealing cell-to-cell variation linked to gene expression differences.

The paper quantifies Intron Mediated Enhancement (IME) in C. elegans by measuring protein expression levels using fluorescent reporters and finds a single intron can increase expression by about 50%.