Soo R. Yun

An Explainable AI Framework for Identifying Universal Aging Signatures in Cell Embeddings

ACE identifies universal aging signatures across species by disentangling aging-related gene expression from other biological variations using explainable AI.

Diverse Patterns of Allele-Specific Expression in Healthy Human Tissues

The paper quantifies interindividual variation in allele-specific expression across healthy human tissues using GTEx data, revealing gene-specific patterns and tissue-specific biases.

Maternal histone methyltransferases antagonistically regulate monoallelic expression in C. elegans

The paper identifies maternal histone methyltransferases that antagonistically regulate monoallelic expression in C. elegans intestinal progenitor cells.

Introns Control Stochasticity in Metazoan Gene Expression

The paper shows introns reduce stochasticity in metazoan gene expression by controlling allele bias through a 5-position dependent mechanism.

hsp-16.2 chaperone biomarkers track physiological states of proteome dosage

The paper identifies hsp-16.2 chaperone biomarkers as indicators of proteome dosage states in C. elegans, revealing cell-to-cell variation linked to gene expression differences.

In vivo measurements reveal a single 5’ intron is sufficient to increase protein expression level in C. elegans

The paper quantifies Intron Mediated Enhancement (IME) in C. elegans by measuring protein expression levels using fluorescent reporters and finds a single intron can increase expression by about 50%.