Jeffrey L. Ardell

This study shows that ablating cardiac TRPV1 afferents after completed myocardial infarction reduces arrhythmogenic remodeling and improves cardiac function.

This study investigates how NPY affects L-type Ca2+ channel activity in ventricular myocytes before and after myocardial infarction, finding context-dependent stimulatory and inhibitory effects.

This study compares intrinsic cardiac neurons across humans, mice, and pigs, revealing species-specific differences in structure, function, and neuropeptide expression.

This paper demonstrates spatially-selective vagus nerve stimulation (sVNS) can target cardiac efferent fibers to decrease heart rate without stimulating afferent-related reflexes, improving precision and efficacy of neuromodulation for cardiac disease.

The paper creates a spatially-tracked single-cell transcriptomics map of the right atrial ganglionic plexus, revealing multipotential neuronal phenotypes and a combinatorial neuromodulatory network.

The paper creates a comprehensive neuroanatomic atlas of the RAGP-SAN complex in porcine and human hearts, showing how intrinsic cardiac neurons control SAN automaticity and cardiac function.

The paper identifies peripheral neural circuits regulating heart rate in mice using optogenetic and viral vector strategies, revealing distinct roles of cholinergic and noradrenergic neurons.