Author

William Flanagan

The Francis Crick InstituteORCID 0000-0002-1389-7166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Aleksandar P. IvanoviD· 1 shared Caroline KochiD· 1 shared Christopher W. DunsbyiD· 1 shared Daniel MarksiD· 1 shared Edwin GarcíaiD· 1 shared Hasan MirzaiD· 1 shared Iain A. McNeishiD· 1 shared Joshua B. EdeliD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aleksandar P. IvanovORCID

Mutual co-authors in cluster

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1 paper

Recent·Most cited

Assessing PARP trapping dynamics in ovarian cancer using a CRISPR-engineered FRET biosensor

Daniel Marks, Edwin García, Sunil Kumar, Katie Tyson, Caroline Koch, Aleksandar P. Ivanov, Joshua B. Edel, Hasan Mirza, William Flanagan, Christopher W. Dunsby, P. M. W. French, Iain A. McNeish

This paper develops a CRISPR-engineered FRET biosensor to study PARP trapping dynamics in ovarian cancer cells and identifies reduced trapping in PARPi-resistant models.

Cell Reports Methods · Dec 30, 2025Peer-reviewedCancer Biology