Daniel Marks

This study assesses the reproducibility of a 3D spheroid-based assay across four institutes using dual-view oblique plane microscopy and finds high consistency in treatment effects with low technical noise.

This study uses spatial transcriptomics to compare gene expression in ovarian clear cell carcinoma and adjacent endometriosis across UK and Japanese patients, finding distinct transcriptional patterns by tissue compartment rather than geographic origin.

The paper uses multimodal imaging to show that lysosomes act as a reservoir for PARP inhibitors, leading to heterogeneous drug distribution and response in ovarian cancer.

This paper develops a CRISPR-engineered FRET biosensor to study PARP trapping dynamics in ovarian cancer cells and identifies reduced trapping in PARPi-resistant models.