Joshua B. Edel

The paper tracks mitochondrial gene expression in live neurons using nanotweezers and finds downregulation of MT-ND1 and MT-ATP6 after exposure to α-synuclein aggregates.

This paper develops a nanopore-based assay with machine learning for label-free miRNA detection, showing that a CNN outperforms traditional methods in sensitivity and classification.

This paper develops a CRISPR-engineered FRET biosensor to study PARP trapping dynamics in ovarian cancer cells and identifies reduced trapping in PARPi-resistant models.