Author

Lara Bossini‐Castillo

Wellcome Sanger InstituteORCID 0000-0002-5471-5824Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Blagoje SoskiciD· 3 shared Deborah J. SmythiD· 3 shared Eddie Cano-GameziD· 3 shared Gosia TrynkaiD· 3 shared David F. ToughiD· 2 shared David R. WilléiD· 2 shared Javier Martin· 2 shared Jorge Esparza-Gordillo· 2 shared

Activity by Year

2019-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersGenetics

Blagoje SoskicORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transcriptional landscape of CD4+ T cells in Systemic Sclerosis

Gonzalo Villanueva-Martín, Gonzalo Borrego‐Yaniz, Marialbert Acosta‐Herrera, José Luís Callejas-Rubio, Norberto Ortego, Norbert Mages, Stefan T. Boerno, María Gutiérrez‐Arcelus, Javier Martin, Lara Bossini‐Castillo

This study uses scRNA-seq to characterize CD4+ T cell subpopulations in SSc patients, identifying interferon-driven activation, reduced TNF signaling, and altered Treg states.

bioRxiv · Mar 19, 2026 · PreprintGenetics

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Kirsty Ambridge, Ziying Ke, Julie C. Matte, Lara Bossini‐Castillo, Joanna Kaplanis, Lucia Ramirez-Navarro, Anna Lorenc, Nikolina Nakić, Jorge Esparza-Gordillo, Wendy C. Rowan, David R. Willé, David F. Tough, , Gosia Trynka

The paper maps eQTLs during T cell activation and identifies immune disease risk variants that regulate gene expression dynamics, showing colocalization with disease-associated genes.

Nature Genetics · May 26, 2022Peer-reviewedGenomics

Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases

Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Wendy C. Rowan, Nikolina Nakić, Jorge Esparza-Gordillo, Lara Bossini‐Castillo, David F. Tough, Christopher G. C. Larminie, Paola G. Bronson, David R. Willé, Gosia Trynka

The paper identifies T cell states associated with immune disease variants by analyzing chromatin activity across different activation states.

Nature Genetics · Sep 23, 2019Peer-reviewedGenetics

Immune disease variants modulate gene expression in regulatory CD4+ T cells and inform drug targets

Lara Bossini‐Castillo, Dafni A. Glinos, Natalia Kunowska, Gosia Golda, Abigail Lamikanra, Michaela Spitzer, Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, Claire Cattermole, Kaur Alasoo, Alice Mann, Kousik Kundu, Nicole Soranzo, Ian Dunham, , Gosia Trynka

The paper identifies immune disease variants affecting Treg gene expression and highlights potential drug targets by linking GWAS signals with Treg QTLs.

bioRxiv · May 31, 2019 · PreprintGenetics

Cross-disorder analysis of schizophrenia and 19 immune diseases reveals genetic correlation

Jennie G Pouget, Buhm Han, Yang Wu, Emmanuel Jean-Marie Mignot, Hanna Maria Ollila, Jonathan Barker, Sarah Spain, Nick Dand, Richard C. Trembath, Javier Martin, Maureen D Mayes, Lara Bossini‐Castillo, Elena López-Isac, Ying Jin, Stephanie A. Santorico, , Jo Knight

This paper identifies shared genetic risk factors between schizophrenia and 19 immune diseases, including three variants with pleiotropic effects and significant genetic correlations for several immune diseases.

bioRxiv · Jan 30, 2019 · PreprintGenetics