Kirsty Ambridge

In vitro sexual dimorphism establishment in schistosomes

This paper refines an in vitro protocol for culturing schistosomes to achieve sexual dimorphism, showing that human serum promotes red blood cell digestion and sexual differentiation compared to fetal bovine serum.

Phylo-Plex: A phylogenetically informed, low-cost amplicon sequencing platform for deployable high-resolution genomic epidemiology

Phylo-Plex is a low-cost amplicon sequencing method for high-resolution genomic epidemiology, achieving fine-scale lineage discrimination comparable to whole-genome sequencing in resource-limited settings.

A single-cell atlas of the miracidium larva of the human blood fluke Schistosoma mansoni: cell types, developmental pathways and tissue architecture

Precise identification of cancer cells from allelic imbalances in single cell transcriptomes

The paper identifies cancer cells from single cell transcriptomes by using allelic imbalances to accurately separate cancer from non-cancer cells.

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

The paper maps eQTLs during T cell activation and identifies immune disease risk variants that regulate gene expression dynamics, showing colocalization with disease-associated genes.

Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome

This study uses single-cell RNA-sequencing to analyze fetal bone marrow development and identifies disruptions in hematopoiesis in Down syndrome.

Prevalence, phenotype and architecture of developmental disorders caused by de novo mutation

The paper analyzes de novo mutations in developmental disorders using exome sequencing of 4,293 families, identifying 94 genes and estimating a birth prevalence of 0.22-0.47%.