Borislav Hrisimirov Hristov

TwinC predicts trans-chromosomal DNA contacts using DNA sequence and provides insights into their functional mechanisms.

The paper uses O-MAP to study a cardiac-specific RNA factory around TTN RNA, revealing its chromatin interactions, RNA composition, and role of RBM20 in gene regulation.

Capricorn enhances low-coverage Hi-C contact matrices using a multi-view diffusion model to improve loop detection accuracy across cell lines and chromosomes.

The paper introduces a computational method to identify trans-chromosomal interactions and finds that genes regulated by the same factor co-localize to form RNA factories.

This paper introduces Synmatch, a method to align cells across single-cell modalities by matching neighborhood structures, showing it works well on small datasets and scales to large ones.

ACCOST identifies significant changes in chromatin conformation between Hi-C experiments by accounting for the genomic distance effect, outperforming existing methods.