T cell-specific loss of IRF1 results in defective CD8 T cell activation and antitumor immunity
Lulu Shao, Hridesh Banerjee, Ecem Ünal, Isha Mehta, Jishnu Das, Abdul Rouf Banday, Larry Kane, Saumendra N. Sarkar
This study shows that T cell-specific loss of IRF1 impairs CD8 T cell activation and antitumor immunity, despite normal cytotoxic T cell numbers.
bioRxiv · May 18, 2026 · PreprintImmunology