Author

Ecem Ünal

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Abdul Rouf BandayiD· 3 shared Bilal A. Lone· 2 shared Abbas Yousefi-Rad· 1 shared Andrea Borghese ApoloiD· 1 shared Arup Chakraborty· 1 shared Ayşe Gökçe KeşküşiD· 1 shared Dhanusha YesudhasiD· 1 shared Elias B. A. ChandraniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Abdul Rouf BandayORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

APOBEC3 activity and polymerase-ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Kelly E. Butler, Bilal A. Lone, Ecem Ünal, Abdul Rouf Banday

The paper identifies distinct mutational mechanisms for IDH1 R132 hotspot mutations, linking APOBEC3 activity to R132C and polymerase-ε deficiency to R132H.

bioRxiv · Jul 13, 2026 · PreprintCancer Biology

APOBEC3-driven neoantigen-rich cancers co-opt 1q23.3 amplification for tumor-intrinsic immune cloaking

Dhanusha Yesudhas, Bilal A. Lone, Ecem Ünal, Arup Chakraborty, Ayşe Gökçe Keşküş, Jaimie Ryou, KM Butler, Tania Colon Aquino, Abbas Yousefi-Rad, Weiming Yang, Lisa M. Miller Jenkins, Raju R. Chelluri, Elias B. A. Chandran, Vladimir Valera Romero, Salah Boudjadi, , Abdul Rouf Banday

The paper identifies a tumor-intrinsic immune-cloaking mechanism in neoantigen-rich cancers driven by APOBEC3 mutagenesis and 1q23.3 amplification, showing NECTIN4's role in suppressing immune responses.

bioRxiv · Jul 4, 2026 · PreprintCancer Biology

T cell-specific loss of IRF1 results in defective CD8 T cell activation and antitumor immunity

Lulu Shao, Hridesh Banerjee, Ecem Ünal, Isha Mehta, Jishnu Das, Abdul Rouf Banday, Larry Kane, Saumendra N. Sarkar

This study shows that T cell-specific loss of IRF1 impairs CD8 T cell activation and antitumor immunity, despite normal cytotoxic T cell numbers.

bioRxiv · May 18, 2026 · PreprintImmunology