Author

Isha Mehta

University of PittsburghORCID 0000-0002-6009-0787Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Jishnu DasiD· 3 shared Abdul Rouf BandayiD· 1 shared Anping XiaiD· 1 shared Bianca M. ColemaniD· 1 shared Ecem Ünal· 1 shared Hridesh BanerjeeiD· 1 shared Ipsita DeyiD· 1 shared Kenta YamamotoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

Jishnu DasORCID

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3 papers

Recent·Most cited

T cell-specific loss of IRF1 results in defective CD8 T cell activation and antitumor immunity

Lulu Shao, Hridesh Banerjee, Ecem Ünal, Isha Mehta, Jishnu Das, Abdul Rouf Banday, Larry Kane, Saumendra N. Sarkar

This study shows that T cell-specific loss of IRF1 impairs CD8 T cell activation and antitumor immunity, despite normal cytotoxic T cell numbers.

bioRxiv · May 18, 2026 · PreprintImmunology

Proteomic Remodeling of the Cochlea During Chronic Suppurative Otitis Media Reveals Immune-Driven Injury Pathways

Ritwija Bhattacharya, Isha D. Mehta, Viktoria Schiel, Jishnu Das, Vincent Yuan, Anping Xia, Peter L. Santa Maria

This study identifies immune-driven injury pathways in the cochlea during chronic suppurative otitis media using proteomic profiling in a murine model.

bioRxiv · Mar 2, 2026 · PreprintImmunology

N6-methyladenosine (m6A) RNA modification restrains antifungal immunity and is a therapeutic target in oral candidiasis

Nicole O. Ponde, Melissa Erin Cook, Isha Mehta, Ipsita Dey, Kenta Yamamoto, Tiffany C. Taylor, Bianca M. Coleman, Shachi Vyas, Rami Bechara, Jishnu Das, Sarah L. Gaffen

This study shows that m6A RNA modification suppresses antifungal immunity in oral epithelial cells and that inhibiting the m6A pathway enhances antimicrobial peptide expression, reducing fungal burden in candidiasis.

bioRxiv · Sep 7, 2025 · PreprintMicrobiology