Cancer BiologybioRxivPreprint
Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotype
Michitaka Nakano, Lyong Heo, Yu-Ping Yang…·Calvin Jay Kuo
The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.
DOI 10.64898/2026.05.06.722767