Joel B. Berletch

The paper investigates how sex chromosome aneuploidy affects gene expression and DNA methylation in different cell types, revealing cell-type specific dosage compensation mechanisms.

This study shows that KDM6A is required for Xist upregulation during X inactivation initiation in mouse ES cells, as its knockout impairs Xist RNA coating and leads to aberrant Xi gene expression.

The paper investigates how CTCF-mediated chromatin insulation and structure regulate escape from X chromosome inactivation in mouse cells, showing that CTCF binding and domain organization are critical for maintaining XCI.

This study shows KDM6A differentially regulates maternal and paternal alleles in mouse genes, with distinct chromatin changes depending on the allele.

The paper develops sci-LIANTI, a single-cell DNA sequencing method, to map meiotic crossovers and chromosome mis-segregation in hybrid mice, finding frequent mitotic segregation during meiosis.

The paper shows Dxz4 orientation controls long-range contacts on the inactive X chromosome, maintaining its bipartite structure through CTCF motif direction.