Cell-type specific allelic dampening of sex-linked genes in sex chromosome aneuploidy
Gala N. Filippova, Elliott Sanger, James MacDonald, He Fang, Camille Groneck, Masaya Takasaki, A. N. Meleshko, Wenxiu Ma, Yajuan Liu, Gang Li, RAN ZHANG, Charles E. Murry, Daniel L. Van Dyke, Anne H Skakkebaek, Claus Højbjerg Gravholt, , Christine M. Distèche
The paper investigates how sex chromosome aneuploidy affects gene expression and DNA methylation in different cell types, revealing cell-type specific dosage compensation mechanisms.
bioRxiv · Apr 21, 2026 · PreprintMolecular Biology