He Fang

The paper investigates how sex chromosome aneuploidy affects gene expression and DNA methylation in different cell types, revealing cell-type specific dosage compensation mechanisms.

This study evaluates Genomic Proximity Mapping (GPM) for detecting structural variants in constitutional disorders, showing high concordance and resolution compared to standard methods.

The paper characterizes an inherited complex chromosomal rearrangement in a family with multisystem anomalies using multiple genomic and functional analyses.

This study shows that KDM6A is required for Xist upregulation during X inactivation initiation in mouse ES cells, as its knockout impairs Xist RNA coating and leads to aberrant Xi gene expression.

The paper investigates how CTCF-mediated chromatin insulation and structure regulate escape from X chromosome inactivation in mouse cells, showing that CTCF binding and domain organization are critical for maintaining XCI.

The paper integrates single-cell RNA-seq, ATAC-seq, and Hi-C data to study nuclear configuration and gene expression changes during stem cell differentiation and X inactivation, revealing discrete structural changes and delayed chromatin compaction.

This study shows that Firre RNA has trans-acting effects on the inactive X chromosome, affecting histone modifications, PRC2 complex components, and chromatin structure.

This study identifies a deletion of FUNDC2 and CMC4 on Xq28 as sufficient to cause hypergonadotropic hypogonadism in men by disrupting apoptosis, inflammation, and FSH regulation.

This paper applies and extends MMD-MA to align single-cell transcriptome and chromatin accessibility data from ~2000 cells, demonstrating its scalability and accuracy.

This study shows KDM6A differentially regulates maternal and paternal alleles in mouse genes, with distinct chromatin changes depending on the allele.

The paper shows RNA stabilizes heterochromatin domains by acting as a structural scaffold, using CUT&RUN.RNase to study RNA's role in chromatin organization.

The paper shows Dxz4 orientation controls long-range contacts on the inactive X chromosome, maintaining its bipartite structure through CTCF motif direction.