Author

Valeria C. Castagna

Consejo Nacional de Investigaciones Científicas y TécnicasORCID 0000-0002-1453-3372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Assay:electronic health records· 1

Frequent Co-Authors

María Eugenia Gómez‐CasatiiD· 4 shared Ana Belén ElgoyheniD· 3 shared Mariano Nicolás Di GuilmiiD· 3 shared Carolina WedemeyeriD· 2 shared Jimena A. BallesteroiD· 2 shared Luis E. BoeroiD· 2 shared Adrián Rodríguez‐ContrerasiD· 1 shared Amanda M. LaueriD· 1 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersNeuroscience

María Eugenia Gómez‐CasatiORCID

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Author profile →

4 papers

Recent·Most cited

Co-release of GABA and ACh from medial olivocochlear neurons fine tunes cochlear efferent inhibition

Tais Castagnola, Valeria C. Castagna, Lester Torres Cadenas, Siân R. Kitcher, Mariano Nicolás Di Guilmi, María Eugenia Gómez‐Casati, Holly J. Beaulac, Paula Inés Buonfiglio, Viviana Dalamón, Eleonora Katz, Ana Belén Elgoyhen, Catherine J.C. Weisz, Juan D. Goutman, Carolina Wedemeyer

The paper shows that GABA and ACh are co-released from MOC terminals, modulating cholinergic inhibition at IHC synapses during development.

Journal of Neuroscience · Oct 2, 2025Peer-reviewedPhysiology

Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure

Valeria C. Castagna, Luis E. Boero, Mariano Nicolás Di Guilmi, Camila Catalano Di Meo, Jimena A. Ballestero, Paul Albert Fuchs, Amanda M. Lauer, Ana Belén Elgoyhen, María Eugenia Gómez‐Casati

This study shows that enhancing medial olivocochlear feedback protects against early noise-induced hearing damage in mice, with long-term auditory benefits.

Journal of Neuroscience · Aug 19, 2025Peer-reviewedNeuroscience

Insights into early cochlear damage induced by potassium channel deficiency

Ezequiel Rías, Camila Carignano, Valeria C. Castagna, Leonardo Dionisio, Jimena A. Ballestero, Giuliana Paolillo, Ingrid Ouwerkerk, María Eugenia Gómez‐Casati, Guillermo F. Spitzmaul

This study shows KCNQ4 deficiency causes cochlear dysfunction by disrupting protein localization, OHC organization, and cell survival, with noise not worsening hair cell damage in the model.

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · Aug 5, 2025Peer-reviewedNeuroscience

Strengthening of the efferent olivocochlear system leads to synaptic dysfunction and tonotopy disruption of a central auditory nucleus

Mariano Nicolás Di Guilmi, Luis E. Boero, Valeria C. Castagna, Adrián Rodríguez‐Contreras, Carolina Wedemeyer, María Eugenia Gómez‐Casati, Ana Belén Elgoyhen

This study shows that enhancing efferent olivocochlear activity disrupts topographic organization and synaptic function in the medial nucleus of the trapezoid body.

Journal of Neuroscience · Jun 19, 2019Peer-reviewedNeuroscience