Mariano Nicolás Di Guilmi

Medial Olivocochlear Activity Modulates Central Auditory Synapse Structure and Function

This study examines how altered medial olivocochlear (MOC) activity affects synaptic structure and function in the auditory brainstem using mouse models.

Co-release of GABA and ACh from medial olivocochlear neurons fine tunes cochlear efferent inhibition

The paper shows that GABA and ACh are co-released from MOC terminals, modulating cholinergic inhibition at IHC synapses during development.

Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure

This study shows that enhancing medial olivocochlear feedback protects against early noise-induced hearing damage in mice, with long-term auditory benefits.

Characterization of developmental changes in spontaneous electrical activity of superior olivary neurons before hearing onset under injectable or volatile anesthesia

This study compares the effects of ketamine/xylazine and isoflurane on the electrical activity of auditory brainstem neurons in neonatal rats during development.

Strengthening of the efferent olivocochlear system leads to synaptic dysfunction and tonotopy disruption of a central auditory nucleus

This study shows that enhancing efferent olivocochlear activity disrupts topographic organization and synaptic function in the medial nucleus of the trapezoid body.