BiochemistrybioRxivPreprint
Unique Gluing Effect of ASXL1 K351 Monoubiquitination Stimulates PR-DUB-Mediated Nucleosomal H2AK119Ub Deubiquitination
Tianyi Zhang, Jiqing Zheng, Zebin Tong…·Lei Liu
The paper identifies a unique mechanism by which ASXL1 K351 monoubiquitination enhances PR-DUB activity through structural stabilization, enabling efficient H2AK119Ub deubiquitination.
DOI 10.1101/2025.04.25.650627