Unique Gluing Effect of ASXL1 K351 Monoubiquitination Stimulates PR-DUB-Mediated Nucleosomal H2AK119Ub Deubiquitination
Tianyi Zhang, Jiqing Zheng, Zebin Tong, Zhiheng Deng, Zaozhen He, Xiangwei Wu, Miao Wang, Yunxiang Du, Ziyu Xu, Shixian Tao, Xiaolin Tian, Haiteng Deng, Man Pan, Huasong Ai, Lei Liu
The paper identifies a unique mechanism by which ASXL1 K351 monoubiquitination enhances PR-DUB activity through structural stabilization, enabling efficient H2AK119Ub deubiquitination.
bioRxiv · Apr 25, 2025 · PreprintBiochemistry