A Cryptic Interfacial Pocket Uncovered in Full CRL4CRBN-IKZF3 Ubiquitylation Complex Enhances IMiD Efficacy
Zhiheng Deng, Huasong Ai, Qiang Shi, Jiawei Liang, Zaozhen He, Jiqing Zheng, Haoxiang Li, Liying Zhang, Wei He, Shixian Tao, Qingyun Zheng, Wei He, Man Pan, Lei Liu
The paper determines cryo-EM structures of IMiDs in full CRL4CRBN complexes, revealing a cryptic interfacial pocket that enhances IMiD efficacy and neosubstrate specificity.
bioRxiv · Jun 8, 2025 · PreprintBiochemistry