Author

Ryan A. Hagenson

Yale UniversityORCID 0000-0001-9750-1925Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2

Frequent Co-Authors

Jason M. SheltzeriD· 3 shared Erin L. SausvilleiD· 2 shared Lu QiaoiD· 2 shared Sanat Mishra· 2 shared Sarah L. ThompsoniD· 2 shared Aditi Swamy· 1 shared Adrian R. KraineriD· 1 shared Anand VasudevaniD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

Jason M. SheltzerORCID

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4 papers

Recent·Most cited

SMURF: soft-segmentation for single-cell reconstruction and topological analysis of spatial transcriptomic data

Juanru Guo, Simona Sarafinovska, Ryan A. Hagenson, Mark C. Valentine, David Y. Chen, William H. McCoy IV, Joseph D. Dougherty, Robi David Mitra, Brian D. Muegge

SMURF improves spatial transcriptomic analysis by accurately assigning mRNAs to cells and revealing gene-expression zonation in tissues.

Nature Communications · Jun 26, 2026Peer-reviewedGenomics

Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell lines

Klaske M. Schukken, Saron M. Akalu, Charles Zou, Pranav K. Kandikuppa, Ryan A. Hagenson, Jessica L. Keane, Mason P. Lynch, Toyoki Yoshimoto, Olaf Klingbeil, Erin L. Sausville, Sanat Mishra, Christopher R. Vakoc, Zuzana Štorchová, Sarah J. Aitken, Jason M. Sheltzer

bioRxiv · Apr 28, 2026 · PreprintCancer Biology

Chromosome engineering to correct a complex rearrangement on Chromosome 8 reveals the effects of 8p syndrome on gene expression and neural differentiation

Sophia N. Lee, Erin C. Banda, Lu Qiao, Sarah L. Thompson, Karan Singh, Ryan A. Hagenson, Teresa Davoli, Stefan F. Pinter, Jason M. Sheltzer

This study corrects a complex Chromosome 8 rearrangement in vitro, identifies differentially expressed genes, and shows partial rescue of neural differentiation defects.

Genome Research · Mar 1, 2026Peer-reviewedDevelopmental Biology

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions

Linda Julian, Lisa Crozier, Devon A. Lukow, Sanat Mishra, Aditi Swamy, Ryan A. Hagenson, Peter C. Sennhenn, Erin L. Sausville, Brianna E. Mendelson, Claudio Chuaqui, Lu Qiao, Anand Vasudevan, Kuan‐Ting Lin, Sonam Bhatia, Thierry Bertomeu, , Jason M. Sheltzer

This study shows CDK11 is critical for cancer cell survival and identifies 1p36 deletions as a biomarker for CDK11 inhibitor sensitivity, but on-target toxicity limits therapeutic efficacy.

bioRxiv · Aug 3, 2025 · PreprintCancer Biology