Andrew Muir

This study shows that TCR-ligand affinity quantitatively modulates transcriptome remodelling in vivo, affecting cell division and interferon response.

The paper shows that transient immune architecture changes during infection protect low-affinity CD8 T-cell priming from Treg inhibition, ensuring broad T-cell responses.

This study compares immune responses and pathogenesis in pigs infected with two porcine respiratory coronavirus strains, finding that a more severe strain induces stronger inflammation and immune responses linked to pneumonia.