Arianne C. Richard

T cell receptor-ligand affinity quantitatively tunes transcriptome remodelling in vivo, inversely regulating cell division and interferon response

This study shows that TCR-ligand affinity quantitatively modulates transcriptome remodelling in vivo, affecting cell division and interferon response.

Transient immune landscape remodelling shapes CD8 T-cell priming during infection

The paper shows that transient immune architecture changes during infection protect low-affinity CD8 T-cell priming from Treg inhibition, ensuring broad T-cell responses.

Pathogenesis and immune response to respiratory coronaviruses in their natural porcine host

This study compares immune responses and pathogenesis in pigs infected with two porcine respiratory coronavirus strains, finding that a more severe strain induces stronger inflammation and immune responses linked to pneumonia.

Robust expression variability testing reveals heterogeneous T cell responses

The paper introduces a method to measure expression variability in single-cell RNA sequencing data, revealing synchronized translational machinery activity in immune cells and new patterns in CD4+ T cell differentiation.

Detection and removal of barcode swapping in single-cell RNA-seq data

The paper quantifies barcode swapping in single-cell RNA-seq data and develops an algorithm to remove swapped reads, reducing artifacts in droplet-based experiments.