Eleni Maniati

The paper defines an RNA-centric landscape of human cell cycle control by profiling various RNA features and identifies key RNA elements involved in cell cycle regulation.

The paper identifies a 6-gene stromal signature, Stroma6, that predicts early relapse in low-risk and chemoresistant breast cancer patients, independent of Oncotype DX results.

This study reconstructs transcriptional trajectories of Fallopian-tube epithelium to show STICs occupy diverse positions along a progression continuum and exhibit variable PARPi resistance signatures.

The paper shows that modifying the tumor microenvironment's extracellular matrix improves chemotherapy response in ovarian cancer models.

This study identifies an 11-amino-acid sequence in the integrin β6 subunit that regulates pancreatic cancer metastasis by affecting cell proliferation, migration, and invasion.

This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.

The paper shows that MSH6 regulates PD-L1 expression through SETD2 recruitment, and MSH6 KO cells have lower microsatellite instability despite higher mutational burden compared to MLH1 KO cells.

This study identifies RSRC2 as a regulator of mitotic fidelity through its interaction with the lncRNA C1QTNF1-AS1, showing defects in chromosome congression when either is lost.

The paper identifies non-coding mutations in enhancer clusters associated with pancreatic ductal adenocarcinoma and validates their functional impact using computational and experimental methods.

The paper identifies DNA copy number alterations and chromosome-scale losses caused by replication stress in non-transformed cells, revealing their role in chromosomal instability and cancer evolution.