Alexandre Lucas

Diet modulates metabolic and hepatic responses to chronic pesticide mixture exposure in mice

This study shows that dietary context affects the metabolic effects of pesticide mixtures in mice, exacerbating glucose intolerance and insulin resistance on a western diet.

Local translation controls early reactive changes in perisynaptic astrocyte processes at pre-symptomatic stages of Alzheimers disease

The paper identifies astrocyte perisynaptic processes as sites of early translational dysregulation in Alzheimer's disease, linking it to synaptic dysfunction and disease initiation.

Antibody-mediated rescue of endogenous retrovirus-induced damage in the demyelinated central nervous system

This study shows that anti-HERV-W ENV antibodies reduce neurodegeneration and improve remyelination in a mouse model of demyelination.

Inhibition of glycolysis in tuberculosis-mediated metabolic rewiring reduces HIV-1 spread across macrophages

This study shows that inhibiting glycolysis in TB-infected macrophages reduces HIV-1 spread by blocking tunneling nanotubes and Siglec-1 expression.